Progesterone, LC-MS/MS

CPT: 84144
Hormones

What This Test Measures

Serum progesterone measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS). More accurate than immunoassay for women on bioidentical hormone therapy (BHRT), as standard immunoassay may cross-react with synthetic progestins and give inaccurate results. Preferred method for monitoring progesterone in BHRT patients.

Preparation

No fasting required
Timing matters: for women not on BHRT, draw on day 21 of cycle (mid-luteal). For BHRT users, check with your provider — timing depends on delivery method and individual protocol.
💬 Patient Community Notes

Recommended for oral progesterone users (Prometrium/micronized progesterone): standard immunoassay can overestimate levels due to cross-reactivity with progesterone metabolites. LC-MS/MS is more accurate for monitoring oral progesterone.

Reflects common practices in thyroid, BHRT, and functional medicine communities. This may differ from standard clinical guidelines. Not medical advice — always discuss with your provider.

General guidelines only. Requirements vary by lab and individual. Confirm with your provider before adjusting any medications.

Turnaround Time

1-3 days

Clinical Notes

Specify LC-MS/MS method when ordering. Quest test code: 30278 (Progesterone, LC/MS/MS). LabCorp offers a similar LCMS assay. This is the recommended method for women on BHRT or using progesterone supplements.

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Lab Codes

Proprietary codes used by each lab for this test.

LabCorp
500167(order)
Quest Diagnostics
17183(order_code)

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For informational purposes only

This page is for educational and research purposes only and does not constitute medical advice, diagnosis, or treatment recommendations. ICD-10 and CPT codes are assigned by your healthcare provider. Always consult a qualified healthcare provider before ordering any lab test or making decisions about your health.