Estradiol (E2)
What This Test Measures
Most potent estrogen; primary sex hormone test for women and estrogen monitoring in men on TRT.
Preparation
TIMING: For cycling women, estradiol varies enormously by cycle day — specify your cycle day on the lab order. Day 3 for baseline (follicular), day 12–14 for peak. For BHRT: draw at trough (just before your next injection/dose) for stable baseline. The BHRT community notes that levels vary widely by delivery method — ranges 'normal' by standard labs (typically <200 pg/mL) may be subtherapeutic for women who feel best at higher levels. Symptom correlation matters as much as numbers. Topical estradiol users: test at trough, not right after application. These notes reflect common practices in BHRT/functional medicine communities.
Reflects common practices in thyroid, BHRT, and functional medicine communities. This may differ from standard clinical guidelines. Not medical advice — always discuss with your provider.
General guidelines only. Requirements vary by lab and individual. Confirm with your provider before adjusting any medications.
Turnaround Time
Varies by lab
Clinical Notes
Standard estradiol; consider "sensitive" assay (LC/MS/MS) for men and children
ICD-10 Codes
Common diagnosis codes associated with this test. Codes are assigned by your provider.
Self-Pay Pricing
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Uses LabCorp draw centers · Not available in NY, NJ, RI, HI, ND, or VT · Membership may be required
Uses Quest Diagnostics network; generally lowest DTC prices; not available in NY, NJ, RI
Uses Labcorp network; known for supplement company; competitive lab test pricing
Uses Quest Diagnostics network; good panel pricing; established DTC provider
Uses both Quest and Labcorp networks; competitive pricing; broad test selection
Uses Quest and Labcorp; no hidden draw or facility fees; moderate pricing
Uses Quest and Labcorp; strong panel bundling; results in 1-3 days
Labcorp consumer-direct platform; 2,000+ locations; results in 1-3 days
Uses Quest and Labcorp networks; offers both individual tests and discounted panels
Primarily uses Labcorp network; popular for hormone panels; higher individual test prices
Quest Diagnostics consumer-direct platform; results in 1-2 days; 2,100+ locations nationwide
Lab Codes
Proprietary codes used by each lab for this test.
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For informational purposes only
This page is for educational and research purposes only and does not constitute medical advice, diagnosis, or treatment recommendations. ICD-10 and CPT codes are assigned by your healthcare provider. Always consult a qualified healthcare provider before ordering any lab test or making decisions about your health.