Anti-TPO (Thyroid Peroxidase Antibody)

CPT: 86376
Thyroid

What This Test Measures

Detects antibodies against thyroid peroxidase enzyme; elevated in Hashimoto's and Graves' disease.

Preparation

No fasting required
No special prep. Biotin can falsely lower antibody readings β€” discontinue 48 hours before testing. Results are not significantly affected by time of day.
πŸ’¬ Patient Community Notes

No special prep required, but be aware that thyroid antibody levels naturally FLUCTUATE β€” they can vary significantly between draws. A single normal result does not definitively rule out Hashimoto’s if clinical suspicion is high. The STTM community notes that any detectable antibodies may be clinically significant, even below the lab’s flagged threshold. A TPO Ab of 30 IU/mL may be β€˜negative’ by lab standards but represent early autoimmune activity. Retest every 3–6 months when tracking interventions. These notes reflect common practices in thyroid/functional medicine communities.

Reflects common practices in thyroid, BHRT, and functional medicine communities. This may differ from standard clinical guidelines. Not medical advice β€” always discuss with your provider.

General guidelines only. Requirements vary by lab and individual. Confirm with your provider before adjusting any medications.

Turnaround Time

Varies by lab

Clinical Notes

Key autoimmune thyroid marker; positive in ~95% of Hashimoto's

ICD-10 Codes

Common diagnosis codes associated with this test. Codes are assigned by your provider.

E03.9Hypothyroidism, unspecified
E05.90Hyperthyroidism, unspecified
E06.3Autoimmune thyroiditis

Self-Pay Pricing

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Walk-In Lab

Uses both Quest and Labcorp networks; competitive pricing; broad test selection

$49.00Order
Life Extension

Uses Labcorp network; known for supplement company; competitive lab test pricing

$49.00Order
Ulta Lab Tests

Uses Quest Diagnostics network; generally lowest DTC prices; not available in NY, NJ, RI

$49.00Order
HealthLabs.com

Uses Quest and Labcorp; strong panel bundling; results in 1-3 days

$59.00Order
Request A Test

Uses Quest and Labcorp networks; offers both individual tests and discounted panels

$59.00Order

Lab Codes

Proprietary codes used by each lab for this test.

American Esoteric Labs
F803(order_code)
ARUP Laboratories
0050550(order_code)
BioReference Laboratories
0412-7(order_code)
Cleveland Clinic
MICRO(mnemonic)
CPL
4513(order_code)
Geisinger Medical Labs
LAB3160(lab_id)
Interpath Laboratory
2754(order_code)
LabCorp
006676(order_code)
Mayo Clinic Labs
ATPO/8336(order_code)
Northwell Health Labs
5915422(order_code)
NYU Langone Health
LAB858(order_code)
Quest Diagnostics
5765(order_code)
Quest Diagnostics
5081(order_code)
Stanford Health Care
ANTIM(order_code)

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For informational purposes only

This page is for educational and research purposes only and does not constitute medical advice, diagnosis, or treatment recommendations. ICD-10 and CPT codes are assigned by your healthcare provider. Always consult a qualified healthcare provider before ordering any lab test or making decisions about your health.